Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.35 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.35 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | SCN4A | P35499 | 1/20 | 0.34 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.34 |
| ▸ | SCN11A | Q9UI33 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22565080 | 1.00 | NCF1 (0.45) | NCF1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL24319641 | 0.94 | NCF1 (0.43) | NCF1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL24319173 | 0.94 | NCF1 (0.43) | NCF1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL24319846 | 0.90 | NCF1 (0.41) | NCF1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL24480584 | 0.89 | NCF1 (0.37) | NCF1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL10196619 | 0.89 | SCN1A (0.42) | NCF1CHRM5ADRA2CACHESCN1A | |
| SCHEMBL17285958 | 0.89 | SCN1A (0.42) | NCF1CHRM5ADRA2CACHESCN1A | |
| SCHEMBL27267970 | 0.86 | ACHE (0.36) | NCF1CHRM5ADRA2CACHEGNAI3 | |
| SCHEMBL23816390 | 0.86 | ACHE (0.32) | NCF1CHRM5ADRA2CACHESCN1A | |
| SCHEMBL17286007 | 0.85 | CHRM5 (0.41) | CHRM5ADRA2CACHESCN1ASCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |