Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 6/20 | 0.53 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21367228 | 0.89 | GNAO1 (0.47) | GNAO1CXCR4SIGMAR1NCF1GNAI3 | |
| SCHEMBL9675410 | 0.85 | GNAO1 (0.57) | GNAO1CXCR4SIGMAR1GNAI3GNAI1 | |
| SCHEMBL30293551 | 0.84 | GNAO1 (0.49) | GNAO1CXCR4SIGMAR1GNAI3GNAI1 | |
| SCHEMBL24320685 | 0.84 | NCF1 (0.46) | GNAO1SIGMAR1NCF1GNAI3GNAI1 | |
| SCHEMBL2769012 | 0.83 | RAD52 (0.51) | GNAO1CXCR4SIGMAR1RAD52CHRM5 | |
| SCHEMBL9728002 | 0.82 | GNAO1 (0.53) | GNAO1NCF1GNAI3GNAI1HRH3 | |
| SCHEMBL30015160 | 0.81 | GNAO1 (0.60) | GNAO1CXCR4SIGMAR1GNAI3GNAI1 | |
| SCHEMBL9886746 | 0.81 | GNAO1 (0.56) | GNAO1CXCR4SIGMAR1GNAI3GNAI1 | |
| SCHEMBL27108004 | 0.79 | CARM1 (0.46) | GNAO1SIGMAR1NCF1GNAI3GNAI1 | |
| SCHEMBL20231124 | 0.79 | GNAO1 (0.42) | GNAO1CXCR4SIGMAR1NCF1GNAI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |