Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 5/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | BCR | P11274 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 6/20 | 0.51 |
| ▸ | FLT3 | P36888 | 3/20 | 0.51 |
| ▸ | IGF1R | P08069 | 2/20 | 0.50 |
| ▸ | INSR | P06213 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2434516 | 0.93 | KIT (0.56) | AURKANTRK1ABL1BCRKIT | |
| SCHEMBL2432693 | 0.92 | LRRK2 (0.46) | AURKANTRK1ABL1BCRKIT | |
| SCHEMBL2437160 | 0.89 | AURKA (0.55) | AURKANTRK1ABL1BCRKIT | |
| SCHEMBL2438142 | 0.89 | AURKA (0.53) | AURKANTRK1ABL1BCRKIT | |
| SCHEMBL740888 | 0.88 | AURKA (0.66) | AURKANTRK1ABL1BCRKIT | |
| SCHEMBL2431925 | 0.85 | KIT (0.47) | AURKANTRK1ABL1BCRKIT | |
| SCHEMBL2437177 | 0.83 | RAB9A (0.49) | AURKAABL1BCRAURKB | |
| SCHEMBL2435084 | 0.83 | ABL1 (0.53) | ABL1BCRKDR | |
| SCHEMBL2432386 | 0.81 | AURKA (0.47) | AURKANTRK1ABL1BCRKIT | |
| SCHEMBL740985 | 0.81 | AURKA (0.77) | AURKAABL1BCRKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007380-B1 | USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2011-09-14 | — | — | EP | claimed |