Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | BCR | P11274 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2433100 | 0.93 | ABL1 (0.52) | RAB9ANPC1ABL1BCRHIF1A | |
| SCHEMBL2439030 | 0.93 | RAB9A (0.46) | RAB9ANPC1ABL1BCRHIF1A | |
| SCHEMBL2435084 | 0.93 | ABL1 (0.53) | ABL1BCRSMN1; SMN2ALDH1A1ENPP2 | |
| SCHEMBL2432693 | 0.89 | LRRK2 (0.46) | ABL1BCRLMNAAURKAAURKB | |
| SCHEMBL2434843 | 0.89 | ABL1 (0.43) | RAB9ANPC1ABL1BCRHIF1A | |
| SCHEMBL739685 | 0.89 | ABL1 (0.56) | RAB9ANPC1ABL1BCRHIF1A | |
| SCHEMBL2431020 | 0.86 | ABL1 (0.60) | RAB9AABL1BCRHIF1AEPAS1 | |
| SCHEMBL2431903 | 0.86 | ABL1 (0.58) | RAB9AABL1BCRHIF1AEPAS1 | |
| SCHEMBL2434312 | 0.86 | ABL1 (0.51) | RAB9ANPC1ABL1BCRHIF1A | |
| SCHEMBL2433994 | 0.86 | ABL1 (0.61) | RAB9AABL1BCRHIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007380-B1 | USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2011-09-14 | — | — | EP | claimed |