⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25571652 | 0.81 | CHRM5 (0.40) | — | |
| SCHEMBL24319334 | 0.77 | — | — | |
| SCHEMBL24319188 | 0.76 | NCF1 (0.41) | — | |
| SCHEMBL20323643 | 0.75 | ACHE (0.34) | — | |
| SCHEMBL24319650 | 0.75 | CACNA2D1 (0.37) | — | |
| SCHEMBL25324905 | 0.72 | JAK2 (0.33) | — | |
| SCHEMBL3061830 | 0.72 | — | — | |
| SCHEMBL20881807 | 0.72 | CHRM5 (0.54) | — | |
| SCHEMBL25026748 | 0.72 | TSHR (0.32) | — | |
| SCHEMBL24891072 | 0.71 | CHRM5 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |