Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 9/20 | 0.45 |
| ▸ | GRM5 | P41594 | 8/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LIPC | P11150 | 1/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31063255 | 0.86 | TLR7 (0.46) | TLR7NAMPTPDK4GRM1GRM5 | |
| SCHEMBL25377894 | 0.85 | TLR7 (0.50) | TLR7NAMPTPDK4GRM1GRM5 | |
| SCHEMBL30582088 | 0.85 | TLR7 (0.50) | TLR7NAMPTPDK4GRM1GRM5 | |
| SCHEMBL14710349 | 0.85 | NAMPT (0.53) | NAMPTPDK4GRM1GRM5WNT3A | |
| SCHEMBL29707399 | 0.84 | TLR7 (0.53) | TLR7NAMPTPDK4GRM1GRM5 | |
| SCHEMBL15178435 | 0.82 | NAMPT (0.54) | TLR7NAMPTPDK4GRM1GRM5 | |
| SCHEMBL6366609 | 0.82 | NAMPT (0.56) | TLR7NAMPTPDK4GRM1GRM5 | |
| SCHEMBL31174297 | 0.82 | NAMPT (0.56) | TLR7NAMPTPDK4GRM1GRM5 | |
| SCHEMBL31342062 | 0.81 | PDK4 (0.50) | NAMPTPDK4GRM1GRM5WNT3A | |
| SCHEMBL29566866 | 0.80 | NAMPT (0.54) | TLR7NAMPTPDK4GRM1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4204418-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2023-07-05 | — | — | EP | disclosed |
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |