Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | PRKDC | P78527 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25134014 | 0.86 | ALDH1A1 (0.47) | ALDH1A1PRKDCNPC1RAB9APOLB | |
| SCHEMBL29927711 | 0.86 | ALDH1A1 (0.47) | ALDH1A1PRKDCNPC1RAB9APOLB | |
| SCHEMBL27370423 | 0.79 | ALDH1A1 (0.36) | ALDH1A1PRKDCNPC1RAB9APOLB | |
| SCHEMBL24319289 | 0.78 | ALDH1A1 (0.36) | ALDH1A1NPC1RAB9APOLBLMNA | |
| SCHEMBL23753987 | 0.78 | IP6K1 (0.38) | ALDH1A1PRKDCNPC1RAB9APOLB | |
| SCHEMBL30635253 | 0.76 | MYC (0.38) | ALDH1A1LMNAMAPTHPGDKDM4E | |
| SCHEMBL24319779 | 0.76 | MYC (0.38) | ALDH1A1LMNAMAPTHPGDKDM4E | |
| SCHEMBL23754172 | 0.74 | NPC1 (0.35) | ALDH1A1PRKDCNPC1RAB9APOLB | |
| SCHEMBL29148153 | 0.74 | IGF1R (0.38) | POLBLMNAMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL15475184 | 0.72 | ALDH1A1 (0.56) | ALDH1A1PRKDCNPC1RAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |