Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GHSR | Q92847 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20231014 | 0.82 | IGF1R (0.42) | IGF1RHRH3MAPTACHEBACE1 | |
| SCHEMBL31753690 | 0.80 | HRH3 (0.48) | HRH3POLB | |
| SCHEMBL31752769 | 0.77 | CHRNA7 (0.43) | HRH3MAPTPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL31084046 | 0.77 | HRH3 (0.37) | IGF1RHRH3MAPTGHSRACHE | |
| SCHEMBL24319781 | 0.74 | ALDH1A1 (0.43) | MAPTPOLBLMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL24319779 | 0.72 | MYC (0.38) | MAPTKMT2ALMNAMEN1 | |
| SCHEMBL20070902 | 0.72 | HRH3 (0.39) | HRH3BRD4 | |
| SCHEMBL31127688 | 0.72 | IGF1R (0.37) | IGF1RMAPTGHSRLMNASMN1; SMN2 | |
| SCHEMBL31129543 | 0.71 | MAPT (0.33) | MAPTGHSRPOLBKMT2A | |
| SCHEMBL22804336 | 0.70 | ALDH1A1 (0.49) | MAPTPOLBKMT2AUSP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117229286-A | Aromatic compound, preparation method thereof and application thereof in preparation of estrogen receptor degradation agent | 海创药业股份有限公司 | 2023-12-15 | — | — | CN | disclosed |