Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.35 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30516952 | 1.00 | IP6K1 (0.45) | IP6K1POLBACVR1SMN1; SMN2MEN1 | |
| SCHEMBL24320130 | 0.88 | IP6K1 (0.46) | IP6K1POLBACVR1SMN1; SMN2MEN1 | |
| SCHEMBL30516949 | 0.88 | IP6K1 (0.46) | IP6K1POLBACVR1SMN1; SMN2MEN1 | |
| SCHEMBL30704943 | 0.80 | POLB (0.48) | POLBACVR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL24320125 | 0.80 | MEN1 (0.52) | POLBACVR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL30656833 | 0.80 | POLB (0.48) | POLBACVR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL24166072 | 0.80 | POLB (0.48) | POLBACVR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL27157404 | 0.80 | POLB (0.48) | POLBACVR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL30516956 | 0.79 | POLB (0.60) | POLBACVR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8439313 | 0.79 | POLB (0.60) | POLBACVR1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081976-A1 | PIPERIDINYL SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |