Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLP1R | P43220 | 6/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | CCR4 | P51679 | 1/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24147695 | 0.89 | INPPL1 (0.50) | GLP1RMAPK14SIGMAR1INPPL1CYP1A2 | |
| SCHEMBL26914337 | 0.81 | GLP1R (0.44) | GLP1RMAPK14KCNH2INPPL1 | |
| SCHEMBL26914340 | 0.81 | GLP1R (0.44) | GLP1RMAPK14KCNH2INPPL1 | |
| Trifluoroacetic Acid SCHEMBL30662706 | 0.81 | GLP1R (0.48) | GLP1RINPPL1CYP1A2CYP2C9TBXA2R | |
| Hydrochloric Acid SCHEMBL26914560 | 0.80 | GLP1R (0.44) | GLP1RMAPK14KCNH2INPPL1 | |
| Hydrochloric Acid SCHEMBL30662717 | 0.80 | GLP1R (0.44) | GLP1RMAPK14KCNH2INPPL1 | |
| SCHEMBL26913667 | 0.80 | GPR119 (0.57) | GLP1RCCR4 | |
| SCHEMBL23235663 | 0.80 | GLP1R (0.61) | GLP1RCCR4 | |
| SCHEMBL23235709 | 0.79 | MAPK14 (0.44) | MAPK14KCNH2CNR1CYP1A2CYP2C9 | |
| SCHEMBL26914109 | 0.77 | GLP1R (0.48) | GLP1RCCR4CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022078407-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. (US) | 2022-04-21 | — | — | WO | disclosed |