Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 10/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24323333 | 0.90 | ATF4 (0.46) | ATF4MEN1KMT2A | |
| SCHEMBL24322993 | 0.90 | ATF4 (0.46) | ATF4MEN1KMT2A | |
| SCHEMBL24324501 | 0.90 | ATF4 (0.42) | ATF4MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL24324231 | 0.89 | ATF4 (0.44) | ATF4MEN1KMT2A | |
| SCHEMBL24323329 | 0.88 | ATF4 (0.46) | ATF4MEN1KMT2AMAPT | |
| SCHEMBL24323279 | 0.86 | ATF4 (0.47) | ATF4KMT2AMAPTSMN1; SMN2THRB | |
| SCHEMBL19577329 | 0.84 | ATF4 (0.44) | ATF4NPC1 | |
| SCHEMBL24324289 | 0.84 | ATF4 (0.44) | ATF4MEN1KMT2ANPC1 | |
| SCHEMBL19577428 | 0.84 | ATF4 (0.44) | ATF4MEN1KMT2ANPC1 | |
| SCHEMBL19577526 | 0.83 | ATF4 (0.52) | ATF4MEN1KMT2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |