Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 17/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19577428 | 1.00 | ATF4 (0.44) | ATF4ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL19577329 | 0.94 | ATF4 (0.44) | ATF4NPC1RAB9A | |
| SCHEMBL24324231 | 0.91 | ATF4 (0.44) | ATF4ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL24322841 | 0.87 | ATF4 (0.44) | ATF4ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL24322993 | 0.86 | ATF4 (0.46) | ATF4MEN1KMT2A | |
| SCHEMBL24323333 | 0.86 | ATF4 (0.46) | ATF4MEN1KMT2A | |
| SCHEMBL24323038 | 0.84 | ATF4 (0.48) | ATF4 | |
| SCHEMBL24323329 | 0.84 | ATF4 (0.46) | ATF4ALDH1A1MEN1KMT2A | |
| SCHEMBL24323087 | 0.84 | ATF4 (0.43) | ATF4MEN1KMT2ANPC1 | |
| SCHEMBL24323279 | 0.84 | ATF4 (0.47) | ATF4ALDH1A1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |