Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.38 |
| ▸ | LATS1 | O95835 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29600540 | 1.00 | MAPT (0.41) | MAPTKDM4EL3MBTL1PIM1PIM3 | |
| SCHEMBL29601220 | 0.96 | SMPD3 (0.41) | MAPTKDM4EL3MBTL1PIM1PIM3 | |
| SCHEMBL24324615 | 0.96 | SMPD3 (0.41) | MAPTKDM4EL3MBTL1PIM1PIM3 | |
| SCHEMBL1326312 | 0.78 | ALDH1A1 (0.44) | MAPTKDM4EL3MBTL1PIM1PIM3 | |
| SCHEMBL20436549 | 0.75 | PDE10A (0.48) | MAPTKDM4EL3MBTL1BCHEACHE | |
| SCHEMBL24323682 | 0.74 | ALDH1A1 (0.39) | MAPTKDM4EL3MBTL1PIM1PIM3 | |
| SCHEMBL29600541 | 0.74 | ALDH1A1 (0.39) | MAPTKDM4EL3MBTL1PIM1PIM3 | |
| SCHEMBL24324093 | 0.73 | PDE10A (0.46) | KDM4EPIM1PIM3PIM2ALDH1A1 | |
| SCHEMBL24270218 | 0.73 | PDE10A (0.42) | MAPTKDM4EL3MBTL1SMPD3CHRM4 | |
| SCHEMBL24270217 | 0.73 | PDE10A (0.42) | MAPTKDM4EL3MBTL1SMPD3CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076622-A2 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |