Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Genistein. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 known ✓ | Q92731 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | TP53 | P04637 | 6/20 | 0.61 |
| ▸ | HPGD | P15428 | 6/20 | 0.61 |
| ▸ | NPC1 | O15118 | 6/20 | 0.61 |
| ▸ | RAB9A | P51151 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.61 |
| ▸ | ESR1 | P03372 | 4/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | TTR | P02766 | 3/20 | 0.61 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Genistein SCHEMBL2436164 | 0.95 | SMN1; SMN2 (0.56) | MAPTSMN1; SMN2MEN1KMT2ATP53 | |
| Glycitein SCHEMBL360612 | 0.87 | HDAC6 (0.56) | MAPTSMN1; SMN2MEN1KMT2ATP53 | |
| Daidzein SCHEMBL3151489 | 0.87 | KDM4E (0.61) | MAPTSMN1; SMN2MEN1KMT2ATP53 | |
| Aus-131 SCHEMBL2004668 | 0.81 | ESR1 (0.58) | MAPTSMN1; SMN2MEN1KMT2ATP53 | |
| Genistein SCHEMBL19166 | 0.78 | MAPT (1.00) | MAPTSMN1; SMN2MEN1KMT2ATP53 | |
| Genistein SCHEMBL554056 | 0.78 | MAPT (1.00) | MAPTSMN1; SMN2MEN1KMT2ATP53 | |
| Genistein SCHEMBL29352944 | 0.78 | MAPT (1.00) | MAPTSMN1; SMN2MEN1KMT2ATP53 | |
| Genistein SCHEMBL551352 | 0.77 | MAPT (0.97) | MAPTSMN1; SMN2MEN1KMT2ATP53 | |
| Genistein SCHEMBL551801 | 0.77 | MAPT (0.97) | MAPTSMN1; SMN2MEN1KMT2ATP53 | |
| Genistein SCHEMBL551449 | 0.77 | MAPT (0.97) | MAPTSMN1; SMN2MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011108699-A1 | GENE RELATED TO THE ACTION OF ISOFLAVONES | 国立大学法人九州大学 (JP) | 2011-09-09 | — | — | WO | disclosed |