Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glycitein. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 known ✓ | Q92731 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 9/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.50 |
| ▸ | KLK7 | P49862 | 1/20 | 0.49 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | MAOA | P21397 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Genistein SCHEMBL2436164 | 0.92 | SMN1; SMN2 (0.56) | HDAC6RAB9AMAPTNPC1KDM4E | |
| Genistein SCHEMBL2432437 | 0.87 | MAPT (0.61) | HDAC6RAB9AMAPTNPC1KDM4E | |
| Glycitein SCHEMBL4653829 | 0.87 | HDAC6 (0.67) | HDAC6RAB9AMAPTNPC1KDM4E | |
| Glycitein SCHEMBL8065644 | 0.85 | HDAC6 (0.78) | HDAC6RAB9AMAPTNPC1KDM4E | |
| Daidzein SCHEMBL3151489 | 0.85 | KDM4E (0.61) | HDAC6RAB9AMAPTNPC1KDM4E | |
| Glycitein SCHEMBL3928329 | 0.82 | HDAC6 (0.83) | HDAC6RAB9AMAPTNPC1KDM4E | |
| Glycitein SCHEMBL5483545 | 0.79 | HDAC6 (0.91) | HDAC6RAB9AMAPTNPC1KDM4E | |
| Aus-131 SCHEMBL2004668 | 0.76 | ESR1 (0.58) | HDAC6RAB9AMAPTNPC1KDM4E | |
| Formononetin SCHEMBL4223418 | 0.75 | MAPT (0.83) | HDAC6RAB9AMAPTNPC1KDM4E | |
| Glycitein SCHEMBL6578666 | 0.75 | RAB9A (0.85) | HDAC6RAB9AMAPTNPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593570-A2 | FERMENTED SOYA BASED MIXTURE COMPRISING ISOFLAVONES- AGLICONES, EQUOL AND LUNASIL, PROCESS FOR THE PREPARATION AND USES THEREOF IN FOOD, MEDICAL AND COSMETIC FIELDS | Giuliani S.p.A. (IT) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007978-A2 | FERMENTED SOYA BASED MIXTURE COMPRISING ISOFLAVONES- AGLICONES, EQUOL AND LUNASIL, PROCESS FOR THE PREPARATION AND USES THEREOF IN FOOD, MEDICAL AND COSMETIC FIELDS. | GIULIANI S.P.A. (IT) | 2012-01-19 | — | — | WO | disclosed |