Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14393385 | 0.86 | LMNA (0.52) | HPGD | |
| SCHEMBL29339265 | 0.83 | CARM1 (0.45) | P2RX7KDM4ERAB9A | |
| SCHEMBL31359702 | 0.81 | NPC1 (0.55) | P2RX7HPGDCYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL28171335 | 0.81 | HPGD (0.44) | HPGDCYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL13104293 | 0.81 | SETDB1 (0.56) | P2RX7HPGDRAB9A | |
| SCHEMBL1642608 | 0.81 | MAPK8 (0.43) | HPGDCYP3A4CYP2C19L3MBTL1KDM4E | |
| SCHEMBL10202757 | 0.78 | HPGD (0.45) | P2RX7HPGDRAB9A | |
| SCHEMBL28170737 | 0.78 | P2RX7 (0.53) | P2RX7 | |
| SCHEMBL3756353 | 0.77 | NPC1 (0.40) | P2RX7HPGDRAB9A | |
| SCHEMBL24323193 | 0.77 | HPGD (0.39) | P2RX7HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |