Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27229801 | 0.81 | TACR1 (0.49) | TACR1SMN1; SMN2GAACYP4F2CYP4A11 | |
| SCHEMBL23384767 | 0.80 | TACR1 (0.45) | TACR1SMN1; SMN2GAACYP4F2CYP4A11 | |
| SCHEMBL29339279 | 0.77 | GAA (0.50) | TACR1SMN1; SMN2GAAKMT2AMEN1 | |
| SCHEMBL29784651 | 0.75 | DYRK1A (0.43) | TACR1SMN1; SMN2GAACYP4F2CYP4A11 | |
| SCHEMBL23384776 | 0.75 | SMN1; SMN2 (0.40) | TACR1SMN1; SMN2GAAPDE10AL3MBTL1 | |
| SCHEMBL31618677 | 0.74 | CYP4F2 (0.46) | SMN1; SMN2CYP4F2CYP4A11KMT2APOLB | |
| SCHEMBL25045746 | 0.74 | SMN1; SMN2 (0.40) | TACR1SMN1; SMN2PDE10AL3MBTL1KLKB1 | |
| SCHEMBL23384717 | 0.73 | NPC1 (0.52) | TACR1SMN1; SMN2GAAKMT2AMEN1 | |
| SCHEMBL14672755 | 0.72 | TACR1 (0.60) | TACR1SMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL23961312 | 0.72 | MEN1 (0.44) | TACR1CYP4F2CYP4A11L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |