Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALPG | P10696 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31545915 | 0.83 | MAPT (0.55) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL2897385 | 0.83 | MAPT (0.55) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL20390494 | 0.83 | ALDH1A1 (0.60) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL20161498 | 0.82 | ALDH1A1 (0.45) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL2905085 | 0.79 | MAPT (0.57) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL22601938 | 0.79 | MAPT (0.49) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL2905084 | 0.79 | MAPT (0.57) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL413498 | 0.77 | MAPT (0.56) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL11499699 | 0.77 | MAPT (0.58) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL20256177 | 0.77 | MAPT (0.55) | MAPTALDH1A1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076625-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |