Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | DRD4 | P21917 | 4/20 | 0.44 |
| ▸ | DRD3 | P35462 | 4/20 | 0.44 |
| ▸ | BACE1 | P56817 | 9/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2434465 | 0.89 | BACE1 (0.46) | BACE1 | |
| SCHEMBL2434388 | 0.86 | BACE1 (0.46) | DRD4BACE1 | |
| SCHEMBL2439264 | 0.86 | DRD2 (0.44) | DRD2DRD4DRD3BACE1SLC6A4 | |
| SCHEMBL1170623 | 0.83 | BACE1 (0.63) | BACE1 | |
| SCHEMBL2438146 | 0.82 | BACE1 (0.42) | DRD2DRD4DRD3BACE1 | |
| SCHEMBL1170621 | 0.81 | BACE1 (0.52) | DRD2DRD4DRD3BACE1 | |
| SCHEMBL2438577 | 0.76 | BACE1 (0.69) | BACE1 | |
| SCHEMBL2434035 | 0.76 | BACE1 (0.39) | BACE1 | |
| SCHEMBL2433017 | 0.76 | BACE1 (0.45) | BACE1 | |
| SCHEMBL2438454 | 0.74 | BACE1 (0.45) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110224231-A1 | Novel Lactams as Beta Secretase Inhibitors | PFIZER INC. (US) | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224231-A1 | Novel Lactams as Beta Secretase Inhibitors | BACE1, BACE2, APH1B | DRD2 4398/4885DRD4 4536/4885DRD3 4408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.