Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2438146 | 0.92 | BACE1 (0.42) | BACE1DRD4 | |
| SCHEMBL2434465 | 0.89 | BACE1 (0.46) | BACE1 | |
| SCHEMBL2432660 | 0.86 | DRD2 (0.44) | BACE1DRD4 | |
| SCHEMBL2435034 | 0.84 | BACE1 (0.41) | BACE1DRD4SIGMAR1 | |
| SCHEMBL2433017 | 0.80 | BACE1 (0.45) | BACE1 | |
| SCHEMBL2438577 | 0.79 | BACE1 (0.69) | BACE1 | |
| SCHEMBL2434126 | 0.79 | BACE1 (0.40) | BACE1 | |
| SCHEMBL2440279 | 0.79 | BACE1 (0.65) | BACE1 | |
| SCHEMBL2434707 | 0.79 | BACE1 (0.52) | BACE1 | |
| SCHEMBL2430593 | 0.78 | BACE1 (0.56) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110224231-A1 | Novel Lactams as Beta Secretase Inhibitors | PFIZER INC. (US) | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224231-A1 | Novel Lactams as Beta Secretase Inhibitors | BACE1, BACE2, APH1B | BACE1 1/4885DRD4 4536/4885SIGMAR1 3706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.