Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24327019 | 0.73 | ALDH1A1 (0.33) | ALDH1A1MAPK1L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL30919743 | 0.72 | ROCK1 (0.49) | ALDH1A1MAPK1L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL4850144 | 0.71 | HTR2A (0.47) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL9726206 | 0.67 | HTR2A (0.62) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL25499920 | 0.67 | NPC1 (0.53) | ALDH1A1MAPK1SMN1; SMN2LMNAMAPT | |
| SCHEMBL29651265 | 0.67 | NPC1 (0.53) | ALDH1A1MAPK1SMN1; SMN2LMNAMAPT | |
| SCHEMBL7793840 | 0.66 | HTR2A (0.59) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL9726221 | 0.66 | HTR2A (0.64) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL28743736 | 0.66 | NOTUM (0.41) | HTR2ADRD2ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL29651175 | 0.66 | NOTUM (0.41) | HTR2ADRD2ALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022063106-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEIGENE, LTD. (KY) | 2022-03-31 | — | — | WO | disclosed |