Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.43 |
| ▸ | JAK1 | P23458 | 12/20 | 0.43 |
| ▸ | TYK2 | P29597 | 12/20 | 0.43 |
| ▸ | JAK3 | P52333 | 12/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24327405 | 0.88 | JAK2 (0.42) | JAK2JAK1TYK2JAK3KCNH2 | |
| SCHEMBL29601621 | 0.87 | JAK2 (0.41) | JAK2JAK1TYK2JAK3AHR | |
| SCHEMBL24328733 | 0.86 | JAK2 (0.37) | JAK2JAK1TYK2JAK3AHR | |
| SCHEMBL24327971 | 0.85 | JAK2 (0.39) | JAK2JAK1TYK2JAK3RET | |
| SCHEMBL24539477 | 0.82 | JAK2 (0.46) | JAK2JAK1TYK2JAK3AHR | |
| SCHEMBL29600985 | 0.81 | JAK2 (0.34) | JAK2JAK1TYK2JAK3RET | |
| SCHEMBL24327391 | 0.81 | JAK2 (0.39) | JAK2JAK1TYK2JAK3AHR | |
| SCHEMBL24539406 | 0.81 | JAK2 (0.45) | JAK2JAK1TYK2JAK3AHR | |
| SCHEMBL24539407 | 0.81 | JAK2 (0.45) | JAK2JAK1TYK2JAK3AHR | |
| SCHEMBL24327333 | 0.80 | JAK2 (0.44) | JAK2JAK1TYK2JAK3AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114369097-B | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |
| CN-114369097-A | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2022-04-19 | — | — | CN | disclosed |