SCHEMBL24327405 — predicted protein targets

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	JAK2	O60674	14/20	0.42

▸	JAK1	P23458	14/20	0.42

▸	TYK2	P29597	14/20	0.42

▸	JAK3	P52333	13/20	0.42

▸	EPHB4	P54760	1/20	0.39

▸	TEK	Q02763	1/20	0.39

▸	TRPV3	Q8NET8	2/20	0.35

▸	F2RL3	Q96RI0	1/20	0.34

▸	NPBWR1	P48145	1/20	0.34

▸	KCNH2	Q12809	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL24327326	0.88	JAK2 (0.43)	JAK2JAK1TYK2JAK3KCNH2
SCHEMBL24328767	0.82	JAK2 (0.43)	JAK2JAK1TYK2JAK3EPHB4
SCHEMBL24539587	0.82	JAK2 (0.43)	JAK2JAK1TYK2JAK3EPHB4
SCHEMBL24539461	0.81	JAK2 (0.42)	JAK2JAK1TYK2JAK3EPHB4
SCHEMBL24539590	0.81	JAK2 (0.42)	JAK2JAK1TYK2JAK3EPHB4
SCHEMBL24327786	0.78	JAK1 (0.39)	JAK2JAK1TYK2JAK3
SCHEMBL24328770	0.77	EPHB4 (0.41)	JAK2JAK1TYK2JAK3EPHB4
SCHEMBL24327771	0.76	TEK (0.43)	JAK2JAK1TYK2JAK3EPHB4
SCHEMBL24328733	0.76	JAK2 (0.37)	JAK2JAK1TYK2JAK3
SCHEMBL29601621	0.75	JAK2 (0.41)	JAK2JAK1TYK2JAK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2022078356-A1	HETEROAROMATIC AHR INHIBITOR	山东轩竹医药科技有限公司	2022-04-21	—	—	WO	disclosed