Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29661358 | 0.82 | TUBB4A (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL24327361 | 0.82 | TUBB4A (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL24327376 | 0.76 | AKT1 (0.34) | KMT2A | |
| SCHEMBL1013968 | 0.70 | CDK1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL25014389 | 0.68 | CCNA2 (0.39) | — | |
| SCHEMBL30424513 | 0.67 | YTHDC1 (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29015705 | 0.67 | YTHDC1 (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29661402 | 0.67 | YTHDC1 (0.46) | YTHDC1CDK1 | |
| SCHEMBL24327035 | 0.67 | YTHDC1 (0.46) | YTHDC1CDK1 | |
| SCHEMBL183289 | 0.67 | KCNN2 (0.43) | YTHDC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022063106-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEIGENE, LTD. (KY) | 2022-03-31 | — | — | WO | disclosed |