Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | AXL | P30530 | 4/20 | 0.40 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | HAT1 | O14929 | 3/20 | 0.35 |
| ▸ | EP300 | Q09472 | 3/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24328755 | 0.82 | MAPK1 (0.39) | AHRMAPK1AXLPIM1CNR1 | |
| SCHEMBL29738270 | 0.75 | AHR (0.44) | AHRMAPK1TTKCNR1CNR2 | |
| SCHEMBL29738275 | 0.75 | AHR (0.44) | AHRMAPK1TTKCNR1CNR2 | |
| SCHEMBL24327768 | 0.74 | AHR (0.42) | AHRMAPK1TTKCNR1CNR2 | |
| SCHEMBL24327393 | 0.73 | AHR (0.42) | AHRTTKKITSYK | |
| SCHEMBL24327399 | 0.73 | AHR (0.41) | AHRTTKCNR1CNR2JAK2 | |
| SCHEMBL24327395 | 0.73 | JAK2 (0.44) | AHRMAPK1TTKCNR1CNR2 | |
| SCHEMBL24327333 | 0.73 | JAK2 (0.44) | AHRTTKCNR1CNR2JAK2 | |
| SCHEMBL24327328 | 0.73 | JAK2 (0.44) | AHRTTKCNR1CNR2JAK2 | |
| SCHEMBL24327400 | 0.73 | AHR (0.41) | AHRMAPK1TTKCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |