Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 9/20 | 0.38 |
| ▸ | CCND3 | P30281 | 9/20 | 0.38 |
| ▸ | CDK9 | P50750 | 9/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 9/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.38 |
| ▸ | CDK2 | P24941 | 9/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.36 |
| ▸ | INSR | P06213 | 2/20 | 0.34 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29661404 | 0.83 | CDK7 (0.40) | CDK9ALKINSREGFRIGF1R | |
| SCHEMBL24327552 | 0.83 | CDK7 (0.40) | CDK9ALKINSREGFRIGF1R | |
| SCHEMBL29661362 | 0.74 | ULK1 (0.35) | CCNKCCND3CDK9CDK6CCNA2 | |
| SCHEMBL24326962 | 0.74 | ULK1 (0.35) | CCNKCCND3CDK9CDK6CCNA2 | |
| SCHEMBL25004485 | 0.71 | NOTUM (0.55) | ALKMAP3K7EGFR | |
| SCHEMBL30942601 | 0.71 | CCNK (0.41) | CCNKCCND3CDK9CDK6CCNA2 | |
| SCHEMBL29661342 | 0.71 | CDK9 (0.43) | CCNKCCND3CDK9CDK6CCNA2 | |
| SCHEMBL24327468 | 0.71 | CDK9 (0.43) | CCNKCCND3CDK9CDK6CCNA2 | |
| SCHEMBL30141686 | 0.71 | CCNA2 (0.41) | CCNKCCND3CDK9CDK6CCNA2 | |
| SCHEMBL25014389 | 0.70 | CCNA2 (0.39) | CCNKCCND3CDK9CDK6CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022063106-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEIGENE, LTD. (KY) | 2022-03-31 | — | — | WO | disclosed |