Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.33 |
| ▸ | CDK2 | P24941 | 6/20 | 0.33 |
| ▸ | CCNK | O75909 | 4/20 | 0.33 |
| ▸ | CCND3 | P30281 | 4/20 | 0.33 |
| ▸ | CDK9 | P50750 | 4/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24327605 | 0.88 | MAP4K1 (0.38) | IGF1RCCNA2CDK2CCNKCCND3 | |
| SCHEMBL29661395 | 0.88 | MAP4K1 (0.38) | IGF1RCCNA2CDK2CCNKCCND3 | |
| SCHEMBL24327013 | 0.81 | INSR (0.39) | CCNA2CDK2CCNKCCND3CDK9 | |
| SCHEMBL29661346 | 0.81 | INSR (0.39) | CCNA2CDK2CCNKCCND3CDK9 | |
| SCHEMBL264974 | 0.74 | TP53 (0.47) | CCNA2CDK2CCNKCCND3CDK9 | |
| SCHEMBL15946706 | 0.74 | LRRK2 (0.52) | CCNA2CDK2CCNKCCND3CDK9 | |
| SCHEMBL24328349 | 0.73 | MAP4K1 (0.35) | CCNA2CDK2CCNKCCND3CDK9 | |
| SCHEMBL29661540 | 0.73 | MAP4K1 (0.35) | CCNA2CDK2CCNKCCND3CDK9 | |
| SCHEMBL29661304 | 0.73 | CCNA2 (0.38) | CCNA2CDK2CCNKCCND3CDK9 | |
| SCHEMBL24327015 | 0.73 | CCNA2 (0.38) | CCNA2CDK2CCNKCCND3CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022063106-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEIGENE, LTD. (KY) | 2022-03-31 | — | — | WO | disclosed |