Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 10/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 3/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 9/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24327855 | 0.88 | LRRK2 (0.58) | FGFR3KDRCSF1RFGFR1FGFR2 | |
| SCHEMBL24327947 | 0.87 | FGFR3 (0.48) | FGFR3KDRCSF1RFGFR1FGFR2 | |
| SCHEMBL29498949 | 0.86 | FGFR3 (0.56) | FGFR3KDRCSF1RFGFR1FGFR2 | |
| SCHEMBL24327350 | 0.86 | FGFR3 (0.56) | FGFR3KDRCSF1RFGFR1FGFR2 | |
| SCHEMBL24327370 | 0.84 | FGFR3 (0.51) | FGFR3KDRCSF1RFGFR1FGFR2 | |
| SCHEMBL29498933 | 0.84 | KDR (0.53) | FGFR3KDRCSF1RFGFR1FGFR2 | |
| SCHEMBL24327347 | 0.84 | KDR (0.53) | FGFR3KDRCSF1RFGFR1FGFR2 | |
| SCHEMBL24327324 | 0.83 | FGFR3 (0.50) | FGFR3KDRCSF1RFGFR1FGFR2 | |
| SCHEMBL24327773 | 0.83 | KCNH2 (0.55) | FGFR3FGFR1FGFR2MAPK1 | |
| SCHEMBL24327885 | 0.83 | MAPK1 (0.51) | FGFR3CSF1RFGFR1FGFR2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115698005-B | Fused ring AhR inhibitors | 山东轩竹医药科技有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-114369097-B | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-115698005-A | Fused ring AhR inhibitors | 山东轩竹医药科技有限公司 | 2023-02-03 | — | — | CN | disclosed |
| WO-2022127753-A1 | FUSED RING AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-06-23 | — | — | WO | disclosed |
| WO-2022127753-A1 | FUSED RING AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-06-23 | — | — | WO | disclosed |
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |
| CN-114369097-A | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2022-04-19 | — | — | CN | disclosed |