Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 8/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 8/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24327374 | 0.85 | KCNH2 (0.64) | KCNH2FGFR2FGFR3FGFR1MAPK1 | |
| SCHEMBL29498946 | 0.85 | KCNH2 (0.64) | KCNH2FGFR2FGFR3FGFR1MAPK1 | |
| SCHEMBL29498950 | 0.85 | KCNH2 (0.64) | KCNH2FGFR2FGFR3FGFR1MAPK1 | |
| SCHEMBL29498914 | 0.84 | EPHB4 (0.46) | KCNH2FGFR2FGFR3FGFR1MAPK1 | |
| SCHEMBL24328691 | 0.84 | EPHB4 (0.46) | KCNH2FGFR2FGFR3FGFR1MAPK1 | |
| SCHEMBL24327855 | 0.84 | LRRK2 (0.58) | FGFR2FGFR3FGFR1MAPK1EPHB4 | |
| SCHEMBL24327827 | 0.83 | FGFR3 (0.53) | FGFR2FGFR3FGFR1MAPK1 | |
| SCHEMBL29498947 | 0.82 | MAPK1 (0.51) | FGFR2FGFR3FGFR1MAPK1 | |
| SCHEMBL24327885 | 0.82 | MAPK1 (0.51) | FGFR2FGFR3FGFR1MAPK1 | |
| SCHEMBL24327883 | 0.80 | TEK (0.46) | KCNH2FGFR2FGFR3EPHB4TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114369097-B | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |
| CN-114369097-A | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2022-04-19 | — | — | CN | disclosed |