Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.54 |
| ▸ | ULK1 | O75385 | 2/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.49 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.47 |
| ▸ | PLK1 | P53350 | 2/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24327480 | 0.88 | EGFR (0.57) | EGFRULK1ALKZAP70PLK1 | |
| SCHEMBL26778361 | 0.86 | ALK (0.61) | EGFRULK1ALKZAP70PLK1 | |
| SCHEMBL24328341 | 0.81 | EGFR (0.67) | EGFRALKZAP70IGF1R | |
| SCHEMBL24327452 | 0.81 | EGFR (0.57) | EGFRALKZAP70PLK1IGF1R | |
| SCHEMBL24327078 | 0.80 | PLK1 (0.60) | EGFRULK1ALKZAP70PLK1 | |
| SCHEMBL24327016 | 0.80 | EGFR (0.62) | EGFRALKZAP70IGF1R | |
| SCHEMBL24327484 | 0.80 | EGFR (0.47) | EGFRALKCHEK1AURKAJAK2 | |
| SCHEMBL24327075 | 0.79 | ALK (0.72) | EGFRULK1ALKZAP70PLK1 | |
| SCHEMBL26778462 | 0.79 | ALK (0.62) | EGFRULK1ALKZAP70PLK1 | |
| SCHEMBL24327466 | 0.78 | EGFR (0.65) | EGFRALKZAP70IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022063106-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEIGENE, LTD. (KY) | 2022-03-31 | — | — | WO | disclosed |