Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24328518 | 0.86 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1KDM4EMAPTADRA2C | |
| SCHEMBL7426055 | 0.78 | KDM4E (0.51) | ALDH1A1L3MBTL1KDM4EMAPTADRA2C | |
| SCHEMBL24327497 | 0.77 | GAA (0.36) | ALDH1A1L3MBTL1KDM4EMAPTGAA | |
| SCHEMBL24328562 | 0.75 | KDM4E (0.49) | ALDH1A1L3MBTL1KDM4EMAPTADRA2C | |
| SCHEMBL29661478 | 0.75 | KDM4E (0.49) | ALDH1A1L3MBTL1KDM4EMAPTADRA2C | |
| SCHEMBL972216 | 0.74 | ADRA2C (0.55) | ALDH1A1L3MBTL1KDM4EMAPTADRA2C | |
| SCHEMBL2894409 | 0.72 | ALDH1A1 (0.60) | ALDH1A1L3MBTL1KDM4EMAPTADRA2C | |
| SCHEMBL16514423 | 0.70 | ALDH1A1 (0.62) | ALDH1A1L3MBTL1KDM4EMAPTADRA2C | |
| SCHEMBL18861760 | 0.69 | ALDH1A1 (0.75) | ALDH1A1L3MBTL1KDM4EMAPTADRA2C | |
| SCHEMBL3623865 | 0.69 | ADRA2C (0.62) | ALDH1A1L3MBTL1KDM4EMAPTADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022063106-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEIGENE, LTD. (KY) | 2022-03-31 | — | — | WO | disclosed |