Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29469675 | 1.00 | MAPT (0.39) | MAPTTP53LMNAIDO1RXFP1 | |
| SCHEMBL24333990 | 0.88 | MCOLN3 (0.41) | MAPTTP53LMNAIDO1KMT2A | |
| SCHEMBL29469701 | 0.88 | TSHR (0.43) | MAPTTP53LMNAKAT6AKMT2A | |
| SCHEMBL24333640 | 0.88 | TSHR (0.43) | MAPTTP53LMNAKAT6AKMT2A | |
| SCHEMBL29469724 | 0.88 | MAPT (0.39) | MAPTTP53LMNARXFP1KAT6A | |
| SCHEMBL24333981 | 0.88 | MAPT (0.39) | MAPTTP53LMNARXFP1KAT6A | |
| SCHEMBL24333358 | 0.86 | SCN9A (0.36) | MAPTTP53LMNAKAT6AKMT2A | |
| SCHEMBL24333772 | 0.86 | LMNA (0.36) | MAPTTP53LMNAIDO1RXFP1 | |
| SCHEMBL24333724 | 0.85 | MAPT (0.37) | MAPTTP53LMNARXFP1KMT2A | |
| SCHEMBL29469654 | 0.85 | MAPT (0.37) | MAPTTP53LMNARXFP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |