Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24333640 | 1.00 | TSHR (0.43) | TSHRMEN1KMT2APOLBKAT6A | |
| SCHEMBL29469617 | 0.92 | LMNA (0.41) | TSHRMEN1KMT2AKAT6AMAPT | |
| SCHEMBL24334334 | 0.92 | LMNA (0.41) | TSHRMEN1KMT2AKAT6AMAPT | |
| SCHEMBL24334414 | 0.91 | LMNA (0.48) | TSHRMEN1KMT2APOLBKAT6A | |
| SCHEMBL24333774 | 0.90 | ALDH1A1 (0.44) | TSHRMEN1KMT2APOLBNPSR1 | |
| SCHEMBL24333954 | 0.90 | TP53 (0.42) | TSHRMEN1KMT2AKAT6AMAPT | |
| SCHEMBL24333735 | 0.90 | TP53 (0.36) | MEN1KMT2APOLBKAT6ANPSR1 | |
| SCHEMBL24334463 | 0.90 | ALDH1A1 (0.37) | POLBNPSR1MAPTLMNATP53 | |
| SCHEMBL24334361 | 0.90 | ALDH1A1 (0.39) | TSHRMEN1KMT2APOLBMAPT | |
| SCHEMBL29469664 | 0.90 | ALDH1A1 (0.44) | TSHRMEN1KMT2ANPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | claimed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | claimed |
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |