Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | PDE8B | O95263 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | AHCY | P23526 | 1/20 | 0.36 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24335834 | 1.00 | KDM1A (0.42) | KDM1APDE8BATMHSD17B10HPGD | |
| SCHEMBL21216318 | 0.88 | KDM1A (0.42) | KDM1APDE8BATMHSD17B10HPGD | |
| SCHEMBL21216116 | 0.81 | ATM (0.40) | KDM1APDE8BATMHSD17B10HPGD | |
| SCHEMBL2354644 | 0.81 | ATM (0.51) | KDM1APDE8BATMHSD17B10HPGD | |
| SCHEMBL1551631 | 0.81 | ATM (0.51) | KDM1APDE8BATMHSD17B10HPGD | |
| SCHEMBL2345014 | 0.81 | ATM (0.51) | KDM1APDE8BATMHSD17B10HPGD | |
| SCHEMBL20522096 | 0.81 | HSD17B10 (0.49) | PDE8BATMHSD17B10HPGDOPRD1 | |
| SCHEMBL1401178 | 0.81 | HSD17B10 (0.49) | PDE8BATMHSD17B10HPGDOPRD1 | |
| SCHEMBL282976 | 0.81 | POLB (0.51) | KDM1APDE8BATMHSD17B10HPGD | |
| SCHEMBL192841 | 0.81 | POLB (0.51) | KDM1APDE8BATMHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022064187-A1 | COMPOUNDS AS MODULATORS OF ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1 (ERAP1) | Grey Wolf Therapeutics Limited (GB) | 2022-03-31 | — | — | WO | disclosed |