Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.74 |
| ▸ | NPC1 | O15118 | 5/20 | 0.74 |
| ▸ | RAB9A | P51151 | 5/20 | 0.74 |
| ▸ | LMNA | P02545 | 4/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.73 |
| ▸ | TSHR | P16473 | 1/20 | 0.73 |
| ▸ | HTT | P42858 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.57 |
| ▸ | CACNA1I | Q9P0X4 | 4/20 | 0.57 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | NT5E | P21589 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24335575 | 0.92 | SMN1; SMN2 (0.73) | SMN1; SMN2NPC1RAB9ALMNANPSR1 | |
| SCHEMBL24336241 | 0.90 | LMNA (0.70) | SMN1; SMN2NPC1RAB9ALMNANPSR1 | |
| SCHEMBL24335756 | 0.90 | SMN1; SMN2 (0.91) | SMN1; SMN2NPC1RAB9ALMNANPSR1 | |
| SCHEMBL24335934 | 0.90 | SMN1; SMN2 (0.79) | SMN1; SMN2NPC1RAB9ALMNANPSR1 | |
| SCHEMBL24336248 | 0.89 | SMN1; SMN2 (0.72) | SMN1; SMN2NPC1RAB9ALMNANPSR1 | |
| SCHEMBL24335941 | 0.87 | SMN1; SMN2 (0.67) | SMN1; SMN2NPC1RAB9ALMNANPSR1 | |
| SCHEMBL24336245 | 0.87 | SMN1; SMN2 (0.66) | SMN1; SMN2NPC1RAB9ALMNANPSR1 | |
| SCHEMBL24335950 | 0.87 | SMN1; SMN2 (0.66) | SMN1; SMN2NPC1RAB9ALMNANPSR1 | |
| SCHEMBL24335591 | 0.85 | SMN1; SMN2 (0.64) | SMN1; SMN2NPC1RAB9ALMNANPSR1 | |
| SCHEMBL24335789 | 0.84 | SMN1; SMN2 (0.66) | SMN1; SMN2NPC1RAB9ALMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116438171-A | Substituted pyridine derivatives as SARM1 inhibitors | 努拉生物公司 | 2023-07-14 | — | — | CN | claimed |
| CN-116438171-A | Substituted pyridine derivatives as SARM1 inhibitors | 努拉生物公司 | 2023-07-14 | — | — | CN | disclosed |
| US-20220081417-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | NURA BIO, INC. | 2022-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220081417-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | SARM1, SARNP, ADRM1 | SMN1; SMN2 7/4885NPC1 570/4885RAB9A 833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.