⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL246094 | 0.91 | — | — | |
| SCHEMBL7377390 | 0.91 | — | — | |
| SCHEMBL5965378 | 0.91 | — | — | |
| SCHEMBL6373455 | 0.86 | — | — | |
| SCHEMBL9481280 | 0.81 | — | — | |
| SCHEMBL8740756 | 0.80 | THRB (0.31) | — | |
| SCHEMBL9479472 | 0.79 | ZDHHC7 (0.39) | — | |
| SCHEMBL4048541 | 0.78 | — | — | |
| SCHEMBL7340986 | 0.77 | ZDHHC7 (0.42) | — | |
| SCHEMBL11118483 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 471 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070172517-A1 | Compositions capable of facilitation penetration across a biological barrier | CHIASMA, INC. | 2007-07-26 | — | — | US | claimed |
| US-7094758-B2 | Apoptotic compounds | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2006-08-22 | — | — | US | claimed |
| EP-1670500-A2 | COMPOSITIONS CAPABLE OF FACILITATING PENETRATION ACROSS A BIOLOGICAL BARRIER | Chiasma, Ltd. (IL) | 2006-06-21 | — | — | EP | claimed |
| US-7041784-B2 | Procaspase-3 activation; peptide comprising AX1 wherein X1 is V, I or L (alanine with valine, isoleucine or leucine) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2006-05-09 | — | — | US | claimed |
| US-20060084611-A1 | Apoptotic compounds | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2006-04-20 | — | — | US | claimed |
| WO-2005094785-A2 | COMPOSITIONS CAPABLE OF FACILITATING PENETRATION ACROSS A BIOLOGICAL BARRIER | CHIASMA, LTD. (IL) | 2005-10-13 | — | — | WO | claimed |
| US-20050136103-A1 | Transepithelial delivery of effectorsequentially coupled with a counter ion to the at least one effector and at least one pharmaceutically acceptable hydrophobic agent; translocation, encapsulation | CHIASMA, INC. | 2005-06-23 | — | — | US | claimed |
| US-20040146549-A1 | Amino acid sequences capable of facilitating penetration across a biological barrier | CHIASMA, INC. | 2004-07-29 | — | — | US | claimed |
| US-6608026-B1 | Contacting pathogenic cells with AV peptoid which comprises amino acid sequence Ala-Val-Pro, is fewer than 20 residues in length, has molecular weight less than 1000, and interacts with Inhibitor of Apoptosis protein, to enhance apoptosis | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2003-08-19 | — | — | US | claimed |
| US-12023316-B2 | FAP-activated therapeutic agents, and uses related thereto | BACH BIOSCIENCES, LLC (US) | 2024-07-02 | — | — | US | disclosed |
| US-11925655-B2 | FAP-activated therapeutic agents, and uses related thereto | BACH BIOSCIENCES, LLC (US) | 2024-03-12 | — | — | US | disclosed |
| US-20240025949-A1 | Beta-Arrestin Effectors and Compositions and Methods of Use Thereof | TREVENA, INC. | 2024-01-25 | — | — | US | disclosed |
| EP-4299134-A2 | FAP-ACTIVATED THERAPEUTIC AGENTS, AND USES RELATED THERETO | Bach Biosciences, LLC (US) | 2024-01-03 | — | — | EP | disclosed |
| EP-4262878-A1 | FAP-ACTIVATED RADIOTHERANOSTICS, AND USES RELATED THERETO | TRUSTEES OF TUFTS COLLEGE (US) | 2023-10-25 | — | — | EP | disclosed |
| WO-1994025491-A1 | FIBRIN-TARGETED INHIBITORS OF THROMBIN | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1994-11-10 | — | — | WO | disclosed |
| WO-1994018832-A1 | CD4 MEDIATED MODULATION OF LIPID KINASES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 1994-09-01 | — | — | WO | disclosed |
| WO-1994019002-A1 | REGULATOR REGIONS OF G PROTEINS | THE GENERAL HOSPITAL CORPORATION (US) | 1994-09-01 | — | — | WO | disclosed |
| EP-0518955-A4 | CHYMOTRYPSIN-LIKE PROTEASES AND THEIR INHIBITORS | — | 1993-09-22 | — | — | EP | disclosed |
| EP-0518955-A1 | CHYMOTRYPSIN-LIKE PROTEASES AND THEIR INHIBITORS | CEPHALON, INC. (US) | 1992-12-23 | — | — | EP | disclosed |
| WO-1991013904-A1 | CHYMOTRYPSIN-LIKE PROTEASES AND THEIR INHIBITORS | CEPHALON, INC. (US) | 1991-09-19 | — | — | WO | disclosed |