Normethadone

Normethadone

SCHEMBL24337

CCC(=O)C(CCN(C)C)(c1ccccc1)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OPRM1 P35372 6/20 1.00
DRD3 P35462 4/20 1.00
DRD2 P14416 2/20 1.00
DRD4 P21917 3/20 0.71
OPRK1 P41145 3/20 0.60
KCNH2 Q12809 3/20 0.60
GRIN2D O15399 2/20 0.60
GRIN1 Q05586 2/20 0.60
GRIN2A Q12879 2/20 0.60
GRIN2B Q13224 2/20 0.60
GRIN2C Q14957 2/20 0.60
OPRD1 P41143 2/20 0.60
CYP2B6 P20813 2/20 0.60
CACNA1F O60840 1/20 0.60
ABCB1 P08183 1/20 0.60
CACNA1D Q01668 1/20 0.60
CACNA1S Q13698 1/20 0.60
CACNA1C Q13936 1/20 0.60
MRGPRX2 Q96LB1 1/20 0.60
SMN1; SMN2 Q16637 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Normethadone SCHEMBL1649313 0.98 OPRM1 (0.97) OPRM1DRD3DRD2DRD4OPRK1
SCHEMBL22312321 0.90 OPRM1 (0.82) OPRM1DRD3DRD2DRD4OPRK1
SCHEMBL22313254 0.85 OPRM1 (0.72) OPRM1DRD3DRD2DRD4OPRK1
SCHEMBL18994329 0.82 OPRM1 (0.69) OPRM1DRD3DRD2DRD4OPRK1
SCHEMBL9780534 0.80 OPRM1 (0.67) OPRM1DRD3DRD2DRD4OPRK1
Methane SCHEMBL5604947 0.80 OPRM1 (0.67) OPRM1DRD3DRD2DRD4OPRK1
SCHEMBL17870644 0.80 OPRM1 (0.67) OPRM1DRD3DRD2DRD4OPRK1
SCHEMBL20607354 0.80 OPRM1 (0.66) OPRM1DRD3DRD2DRD4OPRK1
SCHEMBL22313167 0.79 OPRM1 (0.65) OPRM1DRD3DRD2DRD4OPRK1
Hydrochloric Acid SCHEMBL17874190 0.79 OPRM1 (0.65) OPRM1DRD3DRD2DRD4OPRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6893 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119165094-B Method for detecting psychotropic narcotics in environmental sludge based on acidic condition pretreatment and application 浙江省化工产品质量检验站有限公司 2026-05-15 CN claimed
EP-4724049-A1 MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF Catalent Ontario Limited (CA) 2026-04-15 EP claimed
US-20250319074-A1 TREATMENT AND MANAGEMENT OF AUGMENTATION IN RESTLESS LEGS SYNDROME UNIV EAST CAROLINA (US) 2025-10-16 US claimed
US-20250255781-A1 PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-08-14 US claimed
US-12383743-B2 Treatment of addiction and dependency TACA JR ARTURO C (US) 2025-08-12 US claimed
WO-2025150072-A1 A STABLE ORAL PRO-DISPERSION FORMULATION AND IMPLEMENTATIONS THEREOF PULSE PHARMACEUTICALS PVT LTD (IN) 2025-07-17 WO claimed
EP-4581017-A1 NEW N-HETEROARYLBENZAMIDES DERIVATIVES AS FLT3 INHIBITORS Biodol Therapeutics (FR) 2025-07-09 EP claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
US-12296043-B2 Liquisoft capsules PATHEON SOFTGELS INC. (US) 2025-05-13 US claimed
EP-4510999-A1 PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS Bristol-Myers Squibb Company (US) 2025-02-26 EP claimed
US-5654281-A Inhibiting the development of tolerance to and/or dependence on an addictive substance VIRGINIA COMMONWEALTH UNIVERSITY (US) 1997-08-05 US claimed
EP-0785775-A1 MELT-EXTRUDED ORALLY ADMINISTRABLE OPIOID FORMULATIONS Euroceltique S.A. (LU) 1997-07-30 EP claimed
EP-0731694-A4 1996-10-02 EP claimed
EP-0731694-A1 OPIOID FORMULATIONS FOR TREATING PAIN Euroceltique S.A. (LU) 1996-09-18 EP claimed
CN-1130352-A Method for relieving pain by orally administering 24-hour sustained-release opioid dosage form capable of rapidly increasing initial blood concentration of patient EURO CELTIQUE SA (LU) 1996-09-04 CN claimed
WO-1996014058-A1 MELT-EXTRUDED ORALLY ADMINISTRABLE OPIOID FORMULATIONS EURO-CELTIQUE, S.A. (LU) 1996-05-17 WO claimed
WO-1995014460-A1 OPIOID FORMULATIONS FOR TREATING PAIN EURO-CELTIQUE S.A. (LU) 1995-06-01 WO claimed
EP-0647448-A1 Orally administrable opioid formulations having extended duration of effect Euroceltique S.A. (LU) 1995-04-12 EP claimed
EP-0608893-A1 Inhibiting the development of tolerance to and/or dependence on an additive substance VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-08-03 EP claimed
US-4126684-A 4-AMINO-3-P-HALOPHENYLBUTYRIC ACIDS AND THEIR DERIVATIVES USED IN THE CONTROL OF NARCOTIC ABUSE CIBA-GEIGY CORPORATION (US) 1978-11-21 US claimed