Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CBFB | Q13951 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | FRK | P42685 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3074994 | 0.91 | IRAK4 (0.44) | IRAK4HSD17B10CBFBMETKDM4E | |
| SCHEMBL3436681 | 0.83 | NOTUM (0.42) | HSD17B10METKDM4ENSD2ALDH1A1 | |
| SCHEMBL13607537 | 0.81 | IRAK4 (0.39) | IRAK4HSD17B10MPOKDM4ENSD2 | |
| SCHEMBL14909598 | 0.80 | KDM4E (0.58) | IRAK4HSD17B10MPOKDM4ENSD2 | |
| SCHEMBL30995500 | 0.80 | MAP4K4 (0.43) | IRAK4KDM4ENSD2ALDH1A1MAPT | |
| SCHEMBL3436679 | 0.79 | MAPT (0.56) | HSD17B10KDM4ENSD2ALDH1A1MAPT | |
| SCHEMBL3078992 | 0.78 | IRAK4 (0.41) | IRAK4HSD17B10MPOMETKDM4E | |
| SCHEMBL28237663 | 0.78 | MPO (0.46) | IRAK4HSD17B10MPOKDM4EALDH1A1 | |
| SCHEMBL24338407 | 0.77 | KDM4E (0.46) | IRAK4HSD17B10KDM4EALDH1A1MAPT | |
| SCHEMBL24338408 | 0.77 | IRAK4 (0.40) | IRAK4KDM4EALDH1A1FLT3THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115515956-B | Benzimidazole derivative, and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-115515956-A | Benzimidazole derivative and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2022-12-23 | — | — | CN | disclosed |
| WO-2022068772-A1 | BENZIMIDAZOLE DERIVATIVE, AND PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF | 深圳信立泰药业股份有限公司 | 2022-04-07 | — | — | WO | disclosed |