Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17808789 | 0.85 | CYP2C9 (0.47) | MEN1KMT2AMAPTCYP2A13HSD17B10 | |
| SCHEMBL17808786 | 0.69 | HSD17B10 (0.46) | KMT2AMAPTHSD17B10CYP2C9ALOX15 | |
| SCHEMBL24345069 | 0.67 | HSD17B10 (0.47) | KMT2AMAPTHSD17B10CYP2C9ALOX15 | |
| SCHEMBL17808907 | 0.67 | CYP2C9 (0.43) | KMT2AMAPTHSD17B10CYP2C9ALOX15 | |
| SCHEMBL4111089 | 0.67 | CYP2A13 (0.63) | MEN1KMT2AMAPTCYP2A13KCNH2 | |
| SCHEMBL24344159 | 0.66 | CCNE1 (0.38) | MEN1KMT2AKDM5BKDM4E | |
| SCHEMBL23696453 | 0.65 | KDM5A (0.33) | MAPTKDM4E | |
| SCHEMBL24345089 | 0.65 | KDM4E (0.35) | MAPTCYP2A13HSD17B10CYP2C9ALOX15 | |
| SCHEMBL17808743 | 0.65 | CYP2C9 (0.44) | KMT2AMAPTHSD17B10CYP2C9ALOX15 | |
| SCHEMBL8517029 | 0.65 | GAA (0.49) | MEN1KMT2ACYP2A13HSD17B10CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227292-B1 | 4H-PYRIDO[1,2-a]PYRIMIDIN-4-ONE COMPOUNDS | ALTERITY THERAPEUTICS LTD (AU) | 2022-03-09 | — | — | EP | disclosed |