Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.30 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24344246 | 0.84 | PAX8 (0.32) | PAX8ALDH1A1PDPK1 | |
| SCHEMBL31276901 | 0.84 | PAX8 (0.32) | PAX8ALDH1A1PDPK1 | |
| SCHEMBL24344820 | 0.73 | PAX8 (0.35) | PAX8 | |
| SCHEMBL20839016 | 0.71 | PAX8 (0.36) | PAX8ALDH1A1GPR119 | |
| SCHEMBL22986455 | 0.69 | JAK3 (0.39) | PAX8JAK3PDPK1JAK1 | |
| SCHEMBL17362914 | 0.69 | MKNK2 (0.41) | MKNK2PDPK1JAK1 | |
| SCHEMBL8234275 | 0.69 | PAX8 (0.38) | HSD17B10PAX8ALDH1A1 | |
| SCHEMBL3592339 | 0.68 | GRM5 (0.36) | PAX8ALDH1A1PDPK1 | |
| SCHEMBL17362811 | 0.68 | PDPK1 (0.40) | MKNK2JAK3ALDH1A1PDPK1 | |
| SCHEMBL23482877 | 0.68 | CYP1A2 (0.37) | JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076975-A1 | 5- AND 6-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES | ENLIVEN THERAPEUTICS, INC. (US) | 2022-04-14 | — | — | WO | disclosed |