Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | KDM5A | P29375 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | FPR1 | P21462 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17808758 | 0.86 | KDM5B (0.43) | KDM5BKDM4EKDM5AALDH1A1HSD17B10 | |
| SCHEMBL2902371 | 0.79 | KDM4E (0.51) | KDM5BKDM4EKDM5AALDH1A1HSD17B10 | |
| SCHEMBL11364090 | 0.79 | SMN1; SMN2 (0.52) | KDM5BKDM4EALDH1A1HSD17B10LMNA | |
| Hydrochloric Acid SCHEMBL11357932 | 0.78 | KDM4E (0.54) | KDM5BKDM4EKDM5AALDH1A1HSD17B10 | |
| SCHEMBL28467491 | 0.73 | KDM5A (0.40) | KDM5BKDM4EKDM5AALDH1A1CASR | |
| SCHEMBL11455592 | 0.71 | KDM4E (0.43) | KDM5BKDM4EKDM5AALDH1A1HSD17B10 | |
| SCHEMBL10027310 | 0.70 | ALDH1A1 (0.35) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL11357153 | 0.70 | KDM4E (0.55) | KDM5BKDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL11711695 | 0.69 | PTK2 (0.63) | KDM4EKDM5AALDH1A1HSD17B10LMNA | |
| SCHEMBL11362099 | 0.69 | KDM4E (0.49) | KDM5BKDM4EALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227292-B1 | 4H-PYRIDO[1,2-a]PYRIMIDIN-4-ONE COMPOUNDS | ALTERITY THERAPEUTICS LTD (AU) | 2022-03-09 | — | — | EP | disclosed |