Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | TP53 | P04637 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365017 | 0.84 | KDM5A (0.37) | ALDH1A1KDM4EGAAPKMMAPT | |
| SCHEMBL17808732 | 0.83 | MAPT (0.36) | ALDH1A1KDM4EGAAPKMMAPT | |
| SCHEMBL24345063 | 0.78 | CCNE1 (0.39) | KDM4ETP53SMN1; SMN2CDK9GLA | |
| SCHEMBL13313511 | 0.78 | ALDH1A1 (0.49) | ALDH1A1KDM4EGAAMAPTTP53 | |
| SCHEMBL24344138 | 0.77 | HSD17B10 (0.36) | ALDH1A1KDM4EGAAMAPTTP53 | |
| SCHEMBL17808847 | 0.77 | KDM4E (0.60) | ALDH1A1KDM4EGAAPKMMAPT | |
| SCHEMBL10027312 | 0.73 | TP53 (0.53) | ALDH1A1KDM4EGAAMAPTTP53 | |
| SCHEMBL24345093 | 0.73 | ALDH1A1 (0.48) | ALDH1A1KDM4EGAAMAPTTP53 | |
| SCHEMBL24344663 | 0.70 | KDM5B (0.44) | ALDH1A1KDM4EMAPTTP53LMNA | |
| SCHEMBL24316788 | 0.69 | KDM4E (0.43) | ALDH1A1KDM4EGAAPKMTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163760-B2 | Use of pyridopyrimidine compounds in the treatment of gliomas | PRANA BIOTECHNOLOGY LIMITED (AU) | 2012-04-24 | — | — | US | disclosed |