Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NCK1 | P16333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26597375 | 0.77 | RPS6KB1 (0.39) | MAPTROCK1ALDH1A1KDM4ELMNA | |
| SCHEMBL12182 | 0.75 | RXFP1 (0.53) | HTR2AHTR2CCYP2A6CYP1A2MAPT | |
| SCHEMBL21244768 | 0.73 | NR1I2 (0.48) | HTR2AHTR2CCYP2A6NR1I2EGFR | |
| SCHEMBL21907072 | 0.73 | HTR2A (0.39) | HTR2AHTR2CCYP2A6CYP1A2DHFR | |
| SCHEMBL26605074 | 0.71 | USP2 (0.43) | HTR2AHTR2CCYP1A2DHFRSLC2A1 | |
| SCHEMBL13338392 | 0.70 | MEN1 (0.45) | HTR2AHTR2CCYP2A6CYP1A2DHFR | |
| SCHEMBL22005105 | 0.69 | ACLY (0.46) | HTR2AHTR2CCYP2A6CYP1A2MAPT | |
| SCHEMBL27702087 | 0.69 | HTR2A (0.42) | HTR2AHTR2CCYP1A2DHFRSLC2A1 | |
| SCHEMBL1082617 | 0.68 | HTR2A (0.35) | HTR2AHTR2CMAPTRXFP1NR1I2 | |
| SCHEMBL15345130 | 0.67 | HSD17B10 (0.42) | CYP1A2DHFRSLC2A1NR1I2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220112214-A1 | FUSED HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2022-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220112214-A1 | FUSED HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, FRK | HTR2A 2162/4885HTR2C 1908/4885CYP2A6 4106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.