Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24345322 | 0.73 | HTR2A (0.42) | HTR2AHTR2CDHFRKMT2ACYP1A2 | |
| SCHEMBL14386995 | 0.69 | OXER1 (0.54) | — | |
| SCHEMBL30282852 | 0.68 | TLR8 (0.44) | PPARGPPARARORCKMT2AMAPT | |
| SCHEMBL21244768 | 0.68 | NR1I2 (0.48) | HTR2AHTR2CKMT2ACYP2A6NR1I2 | |
| SCHEMBL16452837 | 0.67 | MAPT (0.50) | DHFRKMT2ACYP1A2CYP2A6MAPT | |
| SCHEMBL21323507 | 0.66 | POLB (0.40) | RORCMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL13338392 | 0.65 | MEN1 (0.45) | HTR2AHTR2CDHFRRORCKMT2A | |
| SCHEMBL28932571 | 0.65 | DHFR (0.45) | DHFRPPARGPPARARORCKMT2A | |
| SCHEMBL22005105 | 0.65 | ACLY (0.46) | HTR2AHTR2CKMT2ACYP1A2CYP2A6 | |
| SCHEMBL21359462 | 0.64 | OXER1 (0.46) | PPARGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020055672-A1 | FUSED HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2020-03-19 | — | — | WO | disclosed |