Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | BCR | P11274 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 4/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 7/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 6/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2434523 | 0.97 | ABL1 (0.43) | ABL1BCRAURKAHDAC1PRKD1 | |
| SCHEMBL2436119 | 0.97 | ABL1 (0.43) | ABL1BCRAURKAHDAC1PRKD1 | |
| SCHEMBL739415 | 0.88 | ABL1 (0.53) | ABL1BCRAURKAHDAC1PRKD1 | |
| SCHEMBL2467029 | 0.87 | ABL1 (0.43) | ABL1BCRAURKAHDAC1PRKD1 | |
| SCHEMBL2432388 | 0.87 | FLT3 (0.47) | ABL1BCRAURKAHDAC1FLT3 | |
| SCHEMBL2438137 | 0.87 | AURKA (0.45) | ABL1BCRAURKAFLT3ROCK2 | |
| SCHEMBL2432182 | 0.85 | AURKA (0.41) | ABL1BCRAURKAHDAC1FLT3 | |
| SCHEMBL741142 | 0.85 | ABL1 (0.53) | ABL1BCRAURKAHDAC1PRKD1 | |
| SCHEMBL741580 | 0.85 | ABL1 (0.53) | ABL1BCRAURKAHDAC1PRKD1 | |
| SCHEMBL2431903 | 0.84 | ABL1 (0.58) | ABL1BCRAURKAHDAC1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007380-B1 | USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2011-09-14 | — | — | EP | claimed |