Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | BCR | P11274 | 2/20 | 0.53 |
| ▸ | AURKA | O14965 | 4/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.37 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | PLK1 | P53350 | 2/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | ULK1 | O75385 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741142 | 0.98 | ABL1 (0.53) | ABL1BCRAURKAHDAC1CTNNB1 | |
| SCHEMBL739415 | 0.97 | ABL1 (0.53) | ABL1BCRAURKAHDAC1CTNNB1 | |
| SCHEMBL2436119 | 0.88 | ABL1 (0.43) | ABL1BCRAURKAHDAC1CTNNB1 | |
| SCHEMBL741133 | 0.87 | ABL1 (0.54) | ABL1BCRAURKAHDAC1PRKD1 | |
| SCHEMBL2434523 | 0.87 | ABL1 (0.43) | ABL1BCRAURKAHDAC1CTNNB1 | |
| SCHEMBL3107639 | 0.86 | HDAC1 (0.45) | AURKAHDAC1CTNNB1TCF7L2PRKD1 | |
| SCHEMBL739669 | 0.85 | ABL1 (0.53) | ABL1BCRAURKAHDAC1ROCK2 | |
| SCHEMBL2434540 | 0.85 | ABL1 (0.42) | ABL1BCRAURKAHDAC1CTNNB1 | |
| SCHEMBL743719 | 0.85 | ABL1 (0.55) | ABL1BCRAURKAHDAC1ROCK2 | |
| SCHEMBL740292 | 0.84 | AURKA (0.55) | ABL1BCRAURKACCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138217-B2 | Aurora kinase inhibitors; proliferative disorders; anticancer agents; antitumor agents; N-(1-methyl-1-phenylethyl)-3-((4-morpholin-4-ylbenzoyl)amino)-1H-thieno(2,3-c)pyrazole-5-carboxamide | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-03-20 | — | — | US | claimed |
| EP-2007380-B1 | USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2011-09-14 | — | — | EP | claimed |
| US-8138217-B2 | Aurora kinase inhibitors; proliferative disorders; anticancer agents; antitumor agents; N-(1-methyl-1-phenylethyl)-3-((4-morpholin-4-ylbenzoyl)amino)-1H-thieno(2,3-c)pyrazole-5-carboxamide | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-03-20 | — | — | US | disclosed |
| EP-2007380-B1 | USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2011-09-14 | — | — | EP | disclosed |