SCHEMBL2434593

SCHEMBL2434593

Cc1ccc(C#N)c(S)c1

nearest known ligand 0.46

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
AR P10275 13/20 0.46
TRPV4 Q9HBA0 3/20 0.42
ALDH1A1 P00352 1/20 0.41
CYP2A6 P11509 1/20 0.41
TSHR P16473 1/20 0.38
PKM P14618 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1003862 0.78 ALDH1A1 (0.46) ARALDH1A1CYP2A6TSHRPKM
SCHEMBL30361887 0.76 TSHR (0.52) ARALDH1A1CYP2A6TSHRPKM
SCHEMBL277588 0.76 TSHR (0.52) ARALDH1A1CYP2A6TSHRPKM
SCHEMBL3076757 0.74 TRPV4 (0.43) TRPV4ALDH1A1CYP2A6TSHR
SCHEMBL23192730 0.73 AR (0.42) ARALDH1A1CYP2A6TSHRPKM
SCHEMBL7485092 0.73 MAOB (0.46) ARTRPV4
SCHEMBL410587 0.73 TRPV4 (0.57) ARTRPV4ALDH1A1CYP2A6
SCHEMBL306406 0.73 AR (0.42) ARALDH1A1CYP2A6TSHRPKM
SCHEMBL21872468 0.73 AR (0.42) ARTRPV4ALDH1A1CYP2A6TSHR
SCHEMBL1343600 0.73 AR (0.42) ARALDH1A1CYP2A6TSHRPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109438512-A The preparation method of a kind of aromatic alkyl phosphorous oxide type compound 湖南大学 2019-03-08 CN claimed
US-20230312481-A1 SUBSTITUTED (PHTHALAZIN-1-YLMETHYL)UREAS, SUBSTITUTED N-(PHTHALAZIN-1-YLMETHYL)AMIDES, AND ANALOGUES THEREOF ARBUTUS BIOPHARMA CORP (CA) 2023-10-05 US disclosed
EP-3632443-B1 ANTI-TUMOR EFFECT POTENTIATOR USING A BIPHENYL COMPOUND TAIHO PHARMACEUTICAL CO LTD (JP) 2023-06-07 EP disclosed
CN-109438512-A The preparation method of a kind of aromatic alkyl phosphorous oxide type compound 湖南大学 2019-03-08 CN disclosed
WO-2011109679-A2 INHIBITORS OF 5-LIPOXYGENASE AMIRA PHARMACEUTICALS, INC. (US) 2011-09-09 WO disclosed
WO-2011109679-A2 INHIBITORS OF 5-LIPOXYGENASE AMIRA PHARMACEUTICALS, INC. (US) 2011-09-09 WO disclosed
US-7556918-B2 Color photographic films comprising support having color developable light sensitive silver halide emulsion layers and color dye-forming couplers, used for high speed print reproduction; storage stability FUJIFILM CORPORATION (JP) 2009-07-07 US disclosed
US-7425408-B2 Silver halide color photographic light-sensitive material FUJIFILM CORPORATION (JP) 2008-09-16 US disclosed
US-20080113305-A1 SILVER HALIDE COLOR PHOTOGRAPHIC LIGHT-SENSITIVE MATERIAL FUJIFILM CORPORATION 2008-05-15 US disclosed
CN-1191657-C Non-aqueous electrolyte secondary cell SONY CORP (JP) 2005-03-02 CN disclosed
CN-1568187-A 2H-2,3-dinitrogen phenodiazine-1-ketone and using method thereof ICOS CORP (US) 2005-01-19 CN disclosed
CN-1322028-A Non-aqueous electrolyte secondary cell SONY CORP (JP) 2001-11-14 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230312481-A1 SUBSTITUTED (PHTHALAZIN-1-YLMETHYL)UREAS, SUBSTITUTED N-(PHTHALAZIN-1-YLMETHYL)AMIDES, AND ANALOGUES THEREOF NSD3, PML, NSD1 AR 2186/4885TRPV4 4126/4885ALDH1A1 3447/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.