Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPFFR1 | Q9GZQ6 | 6/20 | 0.54 |
| ▸ | NPFFR2 | Q9Y5X5 | 6/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PPIA | P62937 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15774951 | 0.89 | NPFFR1 (0.54) | NPFFR1NPFFR2CYP2D6ALDH1A1PPIA | |
| SCHEMBL31447501 | 0.88 | NPFFR1 (0.55) | NPFFR1NPFFR2CYP2D6ALDH1A1PPIA | |
| SCHEMBL23538908 | 0.88 | NPFFR1 (0.59) | NPFFR1NPFFR2CYP2D6ALDH1A1CYP3A4 | |
| SCHEMBL4795708 | 0.88 | NPFFR1 (0.57) | NPFFR1NPFFR2CYP2D6ALDH1A1PPIA | |
| SCHEMBL4295050 | 0.88 | NPFFR1 (0.57) | NPFFR1NPFFR2CYP2D6ALDH1A1PPIA | |
| SCHEMBL13738215 | 0.88 | NPFFR1 (0.57) | NPFFR1NPFFR2CYP2D6ALDH1A1PPIA | |
| SCHEMBL1770778 | 0.88 | NPFFR1 (0.57) | NPFFR1NPFFR2CYP2D6ALDH1A1PPIA | |
| SCHEMBL23538736 | 0.84 | NPFFR1 (0.60) | NPFFR1NPFFR2CYP2D6ALDH1A1CYP3A4 | |
| SCHEMBL4299006 | 0.84 | NPFFR1 (0.51) | NPFFR1NPFFR2CYP2D6ALDH1A1PPIA | |
| SCHEMBL6703813 | 0.83 | NPFFR1 (0.61) | NPFFR1NPFFR2CYP2D6ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220106315-A1 | SPIRO-CONDENSED PYRROLIDINE DERIVATIVES AS DEUBIQUITYLATING ENZYMES (DUB) INHIBITORS | MISSION THERAPEUTICS LTD (GB) | 2022-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220106315-A1 | SPIRO-CONDENSED PYRROLIDINE DERIVATIVES AS DEUBIQUITYLATING ENZYMES (DUB) INHIBITORS | OTUB1, UBE2E1, RCE1 | NPFFR1 4052/4885NPFFR2 4610/4885CYP2D6 2562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.