Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 7/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24348240 | 0.93 | MAPT (0.48) | MAPTALDH1A1TSHRHSD17B10AHR | |
| SCHEMBL29605979 | 0.73 | ALDH1A1 (0.49) | MAPTALDH1A1TSHRHSD17B10AHR | |
| SCHEMBL24348830 | 0.72 | MAPT (0.51) | MAPTALDH1A1TSHRHSD17B10AHR | |
| SCHEMBL24348798 | 0.66 | ALDH1A1 (0.46) | MAPTALDH1A1TSHRHSD17B10AHR | |
| SCHEMBL30128134 | 0.63 | ADORA2A (0.53) | MAPTALDH1A1TSHRHSD17B10 | |
| SCHEMBL22063316 | 0.63 | ADORA2A (0.53) | MAPTALDH1A1TSHRHSD17B10 | |
| SCHEMBL30128074 | 0.63 | ALDH1A1 (0.56) | MAPTALDH1A1TSHRHSD17B10AHR | |
| SCHEMBL22063895 | 0.61 | ALDH1A1 (0.50) | MAPTALDH1A1TSHRHSD17B10AHR | |
| SCHEMBL24349594 | 0.61 | MAPT (0.49) | MAPTALDH1A1TSHRHSD17B10AHR | |
| SCHEMBL29606347 | 0.61 | MAPT (0.49) | MAPTALDH1A1TSHRHSD17B10AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220119412-A1 | THIAZOLOPYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2022-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220119412-A1 | THIAZOLOPYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS | ADORA1, ADORA2A, ADORA3 | MAPT 4012/4885ALDH1A1 233/4885TSHR 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.