Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ACP1 | P24666 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12054671 | 0.87 | KIF11 (0.59) | KIF11BRD4NPY5RPPARGGAA | |
| SCHEMBL16658370 | 0.81 | KIF11 (0.53) | KIF11BRD4NPY5RPPARGP2RX1 | |
| SCHEMBL15218437 | 0.81 | KIF11 (0.53) | KIF11BRD4NPY5RPPARGGAA | |
| SCHEMBL397354 | 0.79 | KIF11 (0.51) | KIF11BRD4NPY5RPPARGGAA | |
| SCHEMBL1410405 | 0.79 | ACP1 (0.52) | KIF11BRD4NPY5RPPARGGAA | |
| SCHEMBL13130516 | 0.78 | KIF11 (0.50) | KIF11BRD4NPY5RPPARGGAA | |
| SCHEMBL16715359 | 0.77 | PPARG (0.50) | KIF11BRD4NPY5RPPARGGAA | |
| SCHEMBL4169754 | 0.77 | BRD4 (0.43) | KIF11BRD4MAPTKEAP1 | |
| SCHEMBL15648605 | 0.76 | KIF11 (0.48) | KIF11BRD4NPY5RPPARGGAA | |
| SCHEMBL2875965 | 0.74 | KIF11 (0.47) | KIF11BRD4GAAP2RX1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022083657-A1 | SUBSTITUTED BENZO OR PYRIDOPYRIMIDINE AMINE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 苏州泽璟生物制药股份有限公司 | 2022-04-28 | — | — | WO | disclosed |